Publications Yu Lab at the University of Georgia

Yin, L., Yu, K. S.,Lin, S, Song, X, ;& Yu, X. (2016). Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012) , 134, 213-225. doi: doi.org/10.1016/j.ecoenv.2016.09.001

Shen, L., Yin, L., Yu, K. S., Hofman, M-C;& Yu, X. (2016). High-content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells TOXICOLOGICAL SCIENCES (2016) , ,. doi: 10.1093/toxsci/kfw178

Yin, L., Yu, K. S., Lu, K., & Yu, X. (2016). Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. TOXICOLOGY IN VITRO, 32, 297-309. doi:10.1016/j.tiv.2016.01.010

Harris, S., Hermsen, S. A. B., Yu, X., Hong, S. W., & Faustman, E. M. (2015). Comparison of toxicogenomic responses to phthalate ester exposure in an organotypic testis co-culture model and responses observed in vivo. REPRODUCTIVE TOXICOLOGY, 58, 149-159. doi:10.1016/j.reprotox.2015.10.002

Garner, C. E., Liang, S., Yin, L., & Yu, X. (2015). Physiologically Based Pharmacokinetic Modeling for 1-Bromopropane in F344 Rats Using Gas Uptake Inhalation Experiments. TOXICOLOGICAL SCIENCES, 145(1), 23-36. doi:10.1093/toxsci/kfv018

Wegner, S. H., Yu, X., Shubin, S. P., Griffith, W. C., & Faustman, E. M. (2015). Stage-specific signaling pathways during murine testis development and spermatogenesis: A pathway-based analysis to quantify developmental dynamics. REPRODUCTIVE TOXICOLOGY, 51, 31-39. doi:10.1016/j.reprotox.2014.11.008

Ndejjo, R., Musinguzi, G., Yu, X., Buregyeya, E., Musoke, D., Wang, J. -S., . . . Ssempebwa, J. (2015). Occupational Health Hazards among Healthcare Workers in Kampala, Uganda. Journal of Environmental and Public Health, 2015, 1-9. doi:10.1155/2015/913741

Susanna, W., Xiaozhong, Y., Hee, Y. K., Sean, H., William, C. G., Sungwoo, H., & Elaine, M. F. (2014). Effect of dipentyl phthalate in 3-dimensional in vitro testis co-culture is attenuated by cyclooxygenase-2 inhibition. Journal of Toxicology and Environmental Health Sciences, 6(8), 161-169. doi:10.5897/JTEHS2014.0314

Garner, C. E., & Yu, X. (2014). Species and sex-dependent toxicokinetics of 1-bromopropane: the role of hepatic cytochrome P450 oxidation and glutathione (GSH). XENOBIOTICA, 44(7), 644-656. doi:10.3109/00498254.2013.879624

Amory, J. K., Hong, S., Yu, X., Muller, C. H., Faustman, E., & Goldstein, A. (2014). Melphalan, alone or conjugated to an FSH-beta peptide, kills murine testicular cells in vitro and transiently suppresses murine spermatogenesis in vivo. THERIOGENOLOGY, 82(1), 152-159. doi:10.1016/j.theriogenology.2014.03.014

Yin, L., & Yu, X. (2014). Bisphenol A (BPA) Affects the Spermatogenesis by Disrupting Gene Regulations in Glycomics. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 100(5), 415. 

Wegner, S., Hong, S., Yu, X., & Faustman, E. M. (2013). Preparation of rodent testis co-cultures.. Curr Protoc Toxicol, Chapter 16, Unit-16.10. doi:10.1002/0471140856.tx1610s55

McConnachie, L. A., Botta, D., White, C. C., Weldy, C. S., Wilkerson, H. W., Yu, J. B., . . . Kavanagh, T. J. (2013). The Glutathione Synthesis Gene Gclm Modulates Amphiphilic Polymer-Coated CdSe/ZnS Quantum Dot-Induced Lung Inflammation in Mice. Plos One, 8. doi:10.1371/journal.pone.0064165

Saldutti, L. P., Beyer, B. K., Breslin, W., Brown, T. R., Chapin, R. E., Campion, S., . . . Sasaki, J. C. (2013). In Vitro Testicular Toxicity Models: Opportunities for Advancement via Biomedical Engineering Techniques. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 30(3), 353-377.

Faustman, E. M., Yu, X., Wegner, S. H., & Harris, S. (2011). Opportunities for Integrating Toxicogenomic Approaches for Regulatory Decision Making.. Environmental and Molecular Mutagenesis, 52, S16.

Yu, X. Z., Ponce, R. A., & Faustman, E. M. (2011). Metals Induced Disruption of Ubiquitin Proteasome System, Activation of Stress Signaling and Apoptosis. doi:10.1007/978-94-007-0428-2_14

Wegner, S., Hong, S., Kim, H., Park, J., Yu, X., & Faustman, E. M. (2011). In Vitro Neural Progenitor Cells as a Model for Neurodevelopment. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 91(5), 369. 

Yu, X. Z., Sidhu, J. S., Hong, S., Robinson, J. F., Ponce, R. A., & Faustman, E. M. (2011). Cadmium Induced p53-Dependent Activation of Stress Signaling, Accumulation of Ubiquitinated Proteins, and Apoptosis in Mouse Embryonic Fibroblast Cells. Toxicological Sciences, 120, 403-412. doi:10.1093/toxsci/kfr010

Robinson, J. F., Yu, X. Z., Moreira, E. G., Hong, S. W., & Faustman, E. M. (2011). Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicology and Applied Pharmacology, 250, 117-129. doi:10.1016/j.taap.2010.09.018

Moreira, E. G., Yu, X., Robinson, J. F., Griffith, W., Hong, S. W., Beyer, R. P., . . . Faustman, E. M. (2010). Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. TOXICOLOGY AND APPLIED PHARMACOLOGY, 245(3), 310-325. doi:10.1016/j.taap.2010.03.015

Robinson, J. F., Yu, X., Hong, S., Griffith, W. C., & Faustman, E. M. (2010). Systems-Biology Approach for Characterizing and Assessing the Interaction of Developmental Disease Candidate Genes and Environmental Exposure for Risk Assessment. Birth Defects Research Part a-Clinical and Molecular Teratology, 88, 378.

Robinson, J. F., Griffith, W. C., Yu, X., Hong, S., Kim, E., & Faustman, E. M. (2010). Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. REPRODUCTIVE TOXICOLOGY, 30(2), 284-291. doi:10.1016/j.reprotox.2010.05.009

Robinson, J. F., Griffith, W. C., Yu, X. Z., Hong, S., Kim, E., & Faustman, E. M. (2010). Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reproductive Toxicology, 30, 284-291. doi:10.1016/j.reprotox.2010.05.009

Robinson, J. F., Port, J. A., Yu, X. Z., & Faustman, E. M. (2010). Integrating Genetic and Toxicogenomic Information for Determining Underlying Susceptibility to Developmental Disorders. Birth Defects Research Part a-Clinical and Molecular Teratology, 88, 920-930. doi:10.1002/bdra.20708

Robinson, J. F., Yu, X. Z., Hong, S., Zhou, C. Y., Kim, N., DeMasi, D., & Faustman, E. M. (2010). Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reproductive Toxicology, 29, 279-285. doi:10.1016/j.reprotox.2009.12.004

Robinson, J. F., Guerrette, Z., Yu, X. Z., Hong, S., & Faustman, E. M. (2010). A Systems-Based Approach to Investigate Dose- and Time-Dependent Methylmercury-Induced Gene Expression Response in C57BL/6 Mouse Embryos Undergoing Neurulation. Birth Defects Research Part B-Developmental and Reproductive Toxicology, 89, 188-200. doi:10.1002/bdrb.20241

Yu, X. Z., Robinson, J. F., Sidhu, J. S., Hong, S., & Faustman, E. M. (2010). A System-Based Comparison of Gene Expression Reveals Alterations in Oxidative Stress, Disruption of Ubiquitin--Proteasome System and Altered Cell Cycle Regulation after Exposure to Cadmium and Methylmercury in Mouse Embryonic Fibroblast. Toxicological Sciences, 114, 356-377. doi:10.1093/toxsci/kfq003

Yu, X. Z., Hong, S., Moreira, E. G., & Faustman, E. M. (2009). Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates. Toxicology and Applied Pharmacology, 239, 325-336. doi:10.1016/j.taap.2009.06.014

Robinson, J. F., Yu, X. Z., Hong, S. W., Griffith, W. C., Beyer, R., Kim, E., & Faustman, E. M. (2009). Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation. Toxicological Sciences, 107, 206-219. doi:10.1093/toxsci/kfn221

Maeda, S., Yu, X., Wang, R. -S., & Sakakibara, H. (2008). A pilot study of gene expression analysis in workers with hand-arm vibration syndrome. INDUSTRIAL HEALTH, 46(2), 188-193. doi:10.2486/indhealth.46.188

Yu, X., Robinson, J. F., Gribble, E., Hong, S. W., Sidhu, J. S., & Faustman, E. M. (2008). Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. TOXICOLOGY AND APPLIED PHARMACOLOGY, 233(3), 389-403. doi:10.1016/j.taap.2008.09.016

Robinson, J. F., Yu, X., Hong, S., & Faustman, E. M. (2008). Examination of dose and time dependent arsenic and cadmium-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Research Part a-Clinical and Molecular Teratology, 82, 287.

Yu, X., Hong, S., & Faustman, E. M. (2008). Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures. TOXICOLOGICAL SCIENCES, 104(2), 385-396. doi:10.1093/toxsci/kfn087

Robinson, J. F., Yu, X., Griffith, W. C., Hong, S., Beyer, R. P., & Faustman, E. M. (2007). Metal-induced toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Birth Defects Research Part a-Clinical and Molecular Teratology, 79, 376.

Faustman, E. M., Yu, X., Griffith, W. C., Hanspers, K., Ong, H., Vredevoogd, M. A., & III, D. J. F. (2006). Quantitative interpretation of dose- and time-dependent microarray data using a gene ontology systems biology approach. TOXICOLOGY LETTERS, 164, S301. doi:10.1016/j.toxlet.2006.07.284

Kim, E., Hong, S., Yu, X., & Faustman, E. M. (2006). Characterization of repeated maternal chlorpyriphos exposure induced acetylcholinesterase inhibition in maternal and fetal brain of C57BL/6 mice. Birth Defects Research Part a-Clinical and Molecular Teratology, 76, 394.

Sidhu, J. S., Ponce, R. A., Vredevoogd, M. A., Yu, X. Z., Gribble, E., Hong, S. W., . . . Faustman, E. M. (2006). Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. TOXICOLOGICAL SCIENCES, 89(2), 475-484. doi:10.1093/toxsci/kfj032

Gribble, E. J., Hong, S., Yu, X. Z., & Faustman, E. M. (2006). Association of cell cycle regulatory proteins with cell cycle exit and differentiation in mouse embryonic midbrain neuronal precursor cells.. Neurotoxicology, 27, 929-930.

Yu, X., Griffith, W. C., Hanspers, K., III, D. J. F., Ong, H., Vredevoogd, M. A., & Faustman, E. M. (2006). A system-based approach to interpret dose- and time-dependent microarray data: Quantitative integration of gene ontology analysis for risk assessment. TOXICOLOGICAL SCIENCES, 92(2), 560-577. doi:10.1093/toxsci/kfj184

Yu, X., Griffith, W. C., Hanspers, K., Ong, H., & Faustman, E. M. (2006). A system based approach to identify potential signalling pathways during gonad development from microarray data. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 76(5), 339. 

Yu, X. Z., Sidhu, J. S., Hong, S., & Faustman, E. M. (2005). Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat sertoli cell/gonocyte co-cultures: An improved In vitro model for assessment of male reproductive toxicity. TOXICOLOGICAL SCIENCES, 84(2), 378-393. doi:10.1093/toxsci/kfi085

Yu, X., Sidhu, J., Hong, J. S., & Faustman, E. M. (2005). Effects of cadmium on ubiquitin-proteasome system and stress signaling in a primary sertoli cell-gonocyte co-culture system. Journal of Andrology, 65.

Faustman, E. M., Yu, X., Sidhu, J. S., Hong, S., Kim, E., Robinson, J. F., & Griffith, W. C. (2004). Integration of toxicogenomic and knowledge-based pathway mapping for elucidating shared molecular mechanisms of metal toxicity. Toxicology and Applied Pharmacology, 197, 264.

Ichihara, G., Li, W. H., Ding, X. C., Peng, S. M., Yu, X. Z., Shibata, E., . . . Takeuchi, Y. (2004). A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 45(1), 63-75. doi:10.1002/ajim.10320

Yamada, T., Ichihara, G., Wang, H., Yu, X., Maeda, K., Tsukamura, H., . . . Takeuchi, Y. (2003). Exposure to 1-bromopropane disrupts development of ovarian follicles in adult rats.. TOXICOLOGICAL SCIENCES, 72, 26. 

Yamada, T., Ichihara, G., Wang, H. L., Yu, X. Z., Maeda, K., Tsukamura, H., . . . Takeuchi, Y. (2003). Exposure to 1-bromopropane causes ovarian dysfunction in rats. TOXICOLOGICAL SCIENCES, 71(1), 96-103. doi:10.1093/toxsci/71.1.96

Yu, X., Faustman, E. M., Hong, S., & Sidhu, J. S. (2003). Effects of methyl mercury and cadmium on stress signaling and ubiquitination pathways in a primary Sertoli cell-gonocyte co-culture system.. Toxicological Sciences, 72, 274.

Wang, H. L., Ichihara, G., Ito, H., Kato, K., Kitoh, J., Yamada, T., . . . Takeuchi, Y. (2003). Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane. NEUROTOXICOLOGY, 24(2), 199-206. doi:10.1016/S0161-813X(02)00195-X

Faustman, E. M., Yu, X., Hong, S., & Jidhu, J. S. (2003). An improved primary Sertoli cell-gonocyte co-culture system from neonate rat: In vitro model for the assessment of male reproductive toxicity.. TOXICOLOGICAL SCIENCES, 72, 221. 

Wang, H. L., Ichihara, G., Ito, H., Kato, K., Kitoh, J., Yamada, T., . . . Takeuchi, Y. (2002). Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days. TOXICOLOGICAL SCIENCES, 67(1), 114-120. doi:10.1093/toxsci/67.1.114

Hisanaga, N., Jonai, H., Yu, X., Ogawa, Y., Mori, I., Kamijima, M., . . . Takeuchi, Y. (2002). [Stevens-Johnson syndrome accompanied by acute hepatitis in workers exposed to trichloroethylene or tetrachloroethylene]. Sangyo Eiseigaku Zasshi, 44, 33-49. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11993231

YOSHIDA, R., OGAWA, Y., SHIOJI, I., YU, X., SHIBATA, E., MORI, I., . . . HISANAGA, N. (2001). Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and Biopyrrins Levels among Construction Workers with Asbestos Exposure History.. INDUSTRIAL HEALTH, 39(2), 186-188. doi:10.2486/indhealth.39.186

Yu, X. Z., Ichihara, G., Kitoh, J., Xie, Z. L., Shibata, E., Kamijima, M., & Takeuchi, Y. (2001). Neurotoxicity of 2-bromopropane and 1-bromopropane, alternative solvents for chlorofluorocarbons. ENVIRONMENTAL RESEARCH, 85(1), 48-52. doi:10.1006/enrs.2000.4226

Yu, X. Z., Kubota, H., Wang, R. S., Saegusa, J., Ogawa, Y., Ichihara, G., . . . Hisanaga, N. (2001). Involvement of Bcl-2 family genes and Fas signaling system in primary and secondary male germ cell apoptosis induced by 2-bromopropane in rat. TOXICOLOGY AND APPLIED PHARMACOLOGY, 174(1), 35-48. doi:10.1006/taap.2001.9187

Ichihara, G., Yu, X. Z., Kitoh, J., Asaeda, N., Kumazawa, T., Iwai, H., . . . Takeuchi, Y. (2000). Reproductive toxicity of 1-bromoprapane, a newly introduced alternative to ozone layer depleting solvents, in male rats. TOXICOLOGICAL SCIENCES, 54(2), 416-423. doi:10.1093/toxsci/54.2.416

Ichihara, G., Kitoh, J., Yu, X. Z., Asaeda, N., Iwai, H., Kumazawa, T., . . . Takeuchi, Y. (2000). 1-bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure. TOXICOLOGICAL SCIENCES, 55(1), 116-123. doi:10.1093/toxsci/55.1.116

Ichihara, G., Ding, X. C., Yu, X. Z., Wu, X. D., Kamijima, M., Peng, S. M., . . . Takeuchi, Y. (1999). Occupational health survey on workers exposed to 2-bromopropane at low concentrations. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 35(5), 523-531. doi:10.1002/(SICI)1097-0274(199905)35:5<523::AID-AJIM10>3.0.CO;2-W

Ichihara, G., Ding, X. C., Yu, X. Z., Wu, X. D., Kamijima, M., Peng, S. M., . . . Takeuchi, Y. (1999). Occupational health survey on workers exposed to 2-bromopropane at low concentrations. American Journal of Industrial Medicine, 35, 523-531. doi:10.1002/(Sici)1097-0274(199905)35:5<523::Aid-Ajim10>3.0.Co;2-W

Yin, L., Jin, X. P., Yu, X. Z., & Lin, H. F. (1999). Flow cytometric analysis of the toxicity of nitrofen in cultured keratinocytes. Biomedical and Environmental Sciences, 12, 144-149.

Yu, X. Z., Ichihara, G., Kitoh, J., Xie, Z. L., Shibata, E., Kamijima, M., . . . Takeuchi, Y. (1999). Effect of inhalation exposure to 2-bromopropane on the nervous system in rats. TOXICOLOGY, 135(2-3), 87-93. doi:10.1016/S0300-483X(99)00053-0

Yu, X. Z., Kamijima, M., Ichihara, G., Li, W. X., Kitoh, J., Xie, Z. L., . . . Takeuchi, Y. (1999). 2-bromopropane causes ovarian dysfunction by damaging primordial follicles and their oocytes in female rats. TOXICOLOGY AND APPLIED PHARMACOLOGY, 159(3), 185-193. doi:10.1006/taap.1999.8730

Ichihara, G., Saito, I., Kamijima, M., Yu, X., Shibata, E., Toida, M., & Takeuchi, Y. (1998). Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n -hexane and methyl ethyl ketone. International Archives of Occupational and Environmental Health, 71(2), 100-104. doi:10.1007/s004200050255

Yu, X. Z., Ichihara, G., Kitoh, J., Xie, Z. L., Shibata, E., Kamijima, M., . . . Takeuchi, Y. (1998). Preliminary report on the neurotoxicity of 1-bromopropane, an alternative solvent for chlorofluorocarbons. JOURNAL OF OCCUPATIONAL HEALTH, 40(3), 234-235. doi:10.1539/joh.40.234

YU, X., JOHANSON, G., ICHIHARA, G., SHIBATA, E., KAMIJIMA, M., ONO, Y., & TAKEUCHI, Y. (1998). Physiologically Based Pharmacokinetic Modeling of Metabolic Interactions between n-Hexane and Toluene in Humans.. Journal of Occupational Health, 40(4), 293-301. doi:10.1539/joh.40.293

Ichihara, G., Asaeda, N., Kumazawa, T., Tagawa, Y., Kamijima, M., Yu, X. Z., . . . Takeuchi, Y. (1997). Testicular and hematopoietic toxicity of 2-bromopropane, a substitute for ozone layer-depleting chlorofluorocarbons. JOURNAL OF OCCUPATIONAL HEALTH, 39(1), 57-63. doi:10.1539/joh.39.57

Kamijima, M., Ichihara, G., Kitoh, J., Tsukamura, H., Maeda, K., Yu, X. Z., . . . Takeuchi, Y. (1997). Ovarian toxicity of 2-bromopropane in the non-pregnant female rat. JOURNAL OF OCCUPATIONAL HEALTH, 39(2), 144-149. doi:10.1539/joh.39.144

Nakajima, T., Shimodaira, S., Ichihara, G., Asaeda, N., Kumazawa, T., Iwai, H., . . . Takeuchi, Y. (1997). Histopathologic findings of bone marrow induced by 2-bromopropane in male rats. JOURNAL OF OCCUPATIONAL HEALTH, 39(2), 81-82. doi:10.1539/joh.39.81

Kamijima, M., Ichihara, G., Yu, X. Z., Xie, Z. L., Kitoh, J., Tsukamura, H., . . . Takeuchi, Y. (1997). Disruption in ovarian cyclicity due to 2-bromopropane in the rat. JOURNAL OF OCCUPATIONAL HEALTH, 39(1), 3-4. doi:10.1539/joh.39.3

Nakajima, T., Shimodaira, S., Ichihara, G., Asaeda, N., Kumazawa, T., Iwai, H., . . . Takeuchi, Y. (1997). 2-bromopropane-induced hypoplasia of bone marrow in male rats. JOURNAL OF OCCUPATIONAL HEALTH, 39(3), 228-233. doi:10.1539/joh.39.228

Faustman, E., Robinson, J. F., Yu, X., Hong, S., & Griffith, W. C. (2012). Integrating genetic and toxicogenomic information to understand susceptibility to developmental toxicants. Neurotoxicology and Teratology, 34(3), 377. doi:10.1016/j.ntt.2012.05.029