The overall objective of Dr. Yu's laboratory research is to apply evolving biomedical and computational technologies to explore the relationship between environmental exposures and human diseases, with emphasis on the mechanism, molecular and biochemical markers of exposure, effect, and susceptibility. The ultimate goal is to improve public health by performing state of the art research that develops the scientific basis of methods used in risk assessment. We are currently developing in vitro three-dimensional cell culture models for improved methods to evaluate and predict toxicity, and discover novel Omics' biomarkers. Especially, we are developing multiplex high-content analysis (HCA) to gain mechanistic understanding of mode of action of chemicals.

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